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目的观察氟哌噻吨美利曲辛片(黛力新)对急性心肌梗死(AMI)病人早期溶栓治疗后伴发抑郁的疗效。方法将96例急性下壁心肌梗死(AIMI)病人随机分为观察组与对照组。两组均给予半量瑞替普酶(r-PA)溶栓治疗,观察组予黛力新治疗,对照组给予安慰剂。治疗2周后,观察两组梗死后心绞痛(PIA)发生及抑郁自评量表(SDS)评分的变化。结果观察组梗死后心绞痛(PIA)较对照组显著下降(P<0.05),SDS评分均明显下降(P<0.05)。结论黛力新可明显改善急性心肌梗死后病人其抑郁状态,减少PIA发作。
Objective To observe the curative effect of flupenthixol and melitracen tablet (Deanxit) on the patients with acute myocardial infarction (AMI) after thrombolytic therapy. Methods 96 patients with acute inferior myocardial infarction (AIMI) were randomly divided into observation group and control group. Both groups were given thrombolysis with semi-dose of reteplase (r-PA), and dexamethasone in the observation group and placebo in the control group. After 2 weeks of treatment, the occurrence of post-infarction angina pectoris (PIA) and depression self-rating scale (SDS) scores were observed. Results The infarction angina pectoris (PIA) in the observation group was significantly lower than that in the control group (P <0.05), and the SDS score was significantly decreased (P <0.05). Conclusion Deanxit can significantly improve the depression of patients after acute myocardial infarction and reduce the onset of PIA.