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目的通过观察盐酸氨基葡萄糖、依托芬那酯凝胶治疗颞下颌关节紊乱病(TMD)的临床疗效,探寻治疗老年TMD的有效治疗方法。方法对2008年7月-2011年12月收治的35例老年TMD患者,予口服盐酸氨基葡萄糖胶囊750 mg,2次/d,依托芬那酯凝胶5 cm局部外涂,3～4次/d,治疗时间为6周,并对治疗前、后颞下颌关节疼痛程度和活动度进行临床疗效评价。结果经治疗,35例患者颞下颌关节疼痛缓解,关节活动度亦明显改善;依据疗效评定标准,治愈10例,显效16例,好转7例,无效2例,总有效率达94.3%;治疗过程中,4例出现轻度胃胀、恶心等不适,2例出现局部皮肤轻度瘙痒现象,无1例中途退出或失访。结论盐酸氨基葡萄糖联合依托芬那酯凝胶治疗老年TMD,能缓解关节症状,改善关节活动度,副作用少,值得临床推广运用。
Objective To observe the clinical efficacy of glucosamine hydrochloride and etofenamate gel in the treatment of temporomandibular disorder (TMD) and explore the effective treatment of senile TMD. Methods 35 elderly TMD patients admitted to our hospital from July 2008 to December 2011 were treated with oral administration of 750 mg of Glucosamine Hydrochloride Capsule twice a day for 5 to 5 days followed by epidermis topical 5 cm topical application for 3 to 4 times / d, the treatment time was 6 weeks, and to evaluate the clinical efficacy of temporomandibular joint pain and activity before and after treatment. Results After treatment, the pain of temporomandibular joint was relieved in 35 patients, and the joint mobility was also significantly improved. According to the evaluation criteria of curative effect, 10 cases were cured, 16 cases were markedly improved, 7 cases were improved, 2 cases were ineffective, and the total effective rate was 94.3% , 4 cases of mild bloating, nausea and other discomfort, 2 cases of local skin mild itching phenomenon, no one case quit or lost. Conclusion Glucosamine hydrochloride combined with etofenamate gel in the treatment of elderly patients with TMD can relieve joint symptoms and improve joint activity with less side effects and is worthy of clinical application.