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目的 :评价氨茶碱对缺氧性动物吸入NO肺动脉高压反弹的预防作用。方法 :采用右心漂浮导管检测法 ,由八导生理记录仪记录肺动脉平均压 (mPAP) ,并监测呼吸、心率及动脉血氧分压变化。结果 :急性缺氧猪吸入 10 -5NO后 ,mPAP明显下降 ,突然停止吸入NO而改吸室内空气后 ,下降的mPAP逐渐回升 ,5min时恢复到吸入NO前水平 ,10min时已明显高于吸入NO前水平 ,与此同时 ,缺氧动物血氧分压反较吸入NO前低 ;而当急性缺氧猪在停止吸入NO的同时 ,静脉推注氨茶碱后 ,虽然下降的mPAP有所回升 ,但回升速度明显低于对照组 ,在停止吸入NO 30min时仍低于吸入NO前水平。结论 :氨茶碱对缺氧性动物吸入NO肺动脉高压反弹有明显的预防作用。
Objective: To evaluate the prophylactic effect of aminophylline on the rebound of pulmonary hypertension induced by inhaled oxygen in anoxic animals. Methods: The right pulmonary artery catheterization method was used to record the average pulmonary arterial pressure (mPAP) by eight guided physiology recorder. The changes of respiration, heart rate and arterial partial pressure of oxygen were monitored. Results: Acute hypoxia pigs inhaled 10 -5NO, mPAP significantly decreased, suddenly stopped inhalation of NO and inhalation of indoor air, decreased mPAP gradually rose to 5min before inhalation of NO before the level of 10min was significantly higher than the inhaled NO Before the level, at the same time, the oxygen partial pressure of anoxia animals compared with low before inhalation of NO; and when acute hypoxia pig stopped inhalation of NO at the same time, intravenous injection of aminophylline, though decreased mPAP has picked up, But the recovery rate was significantly lower than the control group, inhaled NO 30min is still lower than the inhaled NO before the level. CONCLUSION: Aminophylline has a significant preventive effect on NO pulmonary hypertension induced by inhalation of anoxic animals.