Studies on Microbial Transformation of Tibetan Capillaris

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[Objective] To explore transformation of neomangiferin into mangiferin under controlled conditions in vitro,so as to increase the content of mangiferin.[Method] Using Tibetan capillaries(Swertia przewalskii Pissjauk) as tested materials,microorganism fermentation was adopted to realize the transformation of neomangiferin into mangiferin.An efficient strain-screening model was established for selecting strains that could secret specific β-glucosidase by combing category of glycosidic bond with strain-screening technique.Furthermore,these screened strains were isolated,purified and identified.[Result] The upgrade rate of mangiferin content was 0.21% by measuring its content before and after fermentation.[Conclusion] This study was beneficial to reasonable development of mangiferin resource from Tibetan capillaris,which would provide pharmacological and pharmacy evidences for its clinical application. [Objective] To explore transformation of neomangiferin into mangiferin under controlled conditions in vitro, so as to increase the content of mangiferin. [Method] Using Tibetan capillaries (Swertia przewalskii Pissjauk) as tested materials, microorganism fermentation was adopted to realize the transformation of neomangiferin Intuitively, the screened strains were isolated, purified and identified. [Result] The upgrade rate of mangiferin content was 0.21% by measuring its content before and after fermentation. [Conclusion] This study was beneficial to reasonable development of mangiferin resource from Tibetan capillaris, which would provide pharmacological and pharmacy evidences for its clinical application.
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