【摘 要】
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Metabolic reprogramming is a recognized cancer hallmark[1]. During cancer initiation and progression, cancer cells need to rewrite their metabolism to meet ener
【机 构】
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Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510220, Chin
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Metabolic reprogramming is a recognized cancer hallmark[1]. During cancer initiation and progression, cancer cells need to rewrite their metabolism to meet energy demands, which is often coordinated with elevated energy production and biosynthetic processes[2]. Metabolic reprogramming in cancer profoundly affects gene expression regulation[3]. Emerging evidence in recent years indicates that the metabolite profile seems to play an important role in epigenetic regulation, although it may have little effect at the genetic level[4-6]. Therefore, metabolic alterations and epigenetic in cancer cells are linked mechanistically. Metabolomics-epigenetic interplay plays a critical role in cancer initiation and progression by sustaining cell proliferation, metastasis, cancer stemness and therapeutic resistance[4,7,8].
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