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目的：探讨护理程序对白血病化疗患者负性情绪及毒副反应的影响。方法选择本院在2010年4月至2014年3月收治的79例白血病化疗患者为研究对象，采用随机分层法分为对照组(39例)和观察组(40例)，对照组予以常规护理，观察组应用护理程序进行护理干预，比较两组患者护理干预前后焦虑抑郁量表(HAD)得分及化疗期间毒副反应症状改善情况。结果观察组HAD-A、HAD-D评分(5.37±4.35、5.56±3.37)明显低于对照组；化疗期间恶心呕吐、呼吸困难、食欲下降、失眠、腹泻以及便秘等毒副反应发生率(35%、20%、20%、5%、20%、12.5%)明显低于对照组( P<0.05)。结论运用护理程序对白血病患者予以针对性地护理干预，能降低患者负性情绪的严重程度，减轻其化疗毒副反应症状。“,”Objective To explore the influence of nursing program on negative emotions and adverse reaction of the leukemia patients undergoing chemotherapy. Methods A total of 79 cases of leukemia patients treated with chem-otherapy from April 2010 to March 2014 in our hospital were enrolled in the study and were divided into control group (39 cases ) and observation group (40 cases) through stratified randomization. The control group was given routine nursing, while the observation group was given nursing intervention by applying the nursing process. The two groups were compared before and after nursing intervention in Hospital Anxiety and Depression Scale ( HAD) score and the im-provement of the adverse reactions during the chemotherapy. Results The HAD-A and HAD-D score ( 5. 37 ± 4. 35 , 5. 56±3. 37) of the observation group were significantly lower than those of the control group (P<0. 05) . The incidence rates of nausea and vomiting, difficulty in breathing, loss of appetite, insomnia, diarrhea , constipation and other ad-verse reactions during chemotherapy of the observation group were significantly lower than those of the control group ( P<0. 05 ) . Conclusions Applying the nursing procedure and providing targeted nursing intervention for the patients with leukemia can reduce the patients′severity of negative emotions, relieve the adverse reactions of chemotherapy.