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目的:观察氟西汀联合圣·约翰草提取物在帕金森病(PD)伴抑郁症治疗中的疗效。方法:随机将78例帕金森伴抑郁患者分成氟西汀和圣·约翰草提取物治疗组38例及对照组40例,治疗前后用汉密顿抑郁量表(HAMD)17项版本进行评分。结果:治疗6周后治疗组HAMD评分显著低于对照组(P<0.01),使用氟西汀联合圣·约翰草提取物治疗的患者在抑郁疗效方面显著优于对照组(P<0.01)。结论:氟西汀联合圣·约翰草提取物可明显改善PD患者的抑郁症状。
Objective: To observe the efficacy of fluoxetine combined with St. John’s wort extract in the treatment of Parkinson’s disease (PD) with depression. Methods: A total of 78 patients with parkinsonism and depression were randomly divided into two groups, 38 patients in the fluoxetine group and St. John’s wort extract group and 40 patients in the control group. The HAMD scores were measured before and after treatment in 17 versions. Results: After 6 weeks of treatment, the HAMD score of the treatment group was significantly lower than that of the control group (P <0.01). Patients treated with fluoxetine plus St. John’s wort extract were significantly better than the control group in depression efficacy (P <0.01). Conclusion: Fluoxetine combined with St. John’s wort extract can significantly improve the symptoms of depression in PD patients.