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研究Coxsachie病毒在感染乳鼠体内的分布情况及其引起的病理变化可以了解这种病毒对乳鼠的发病机制;此外,它对乳鼠的病理变化还有助于诊断它对人所引起的疾病。Melnick及Godman氏等以Coxsachie B-1型病毒由腹腔感染出生后4-5天的乳鼠,发现在感染后的第二天,在其血液、腦、心、肝、肌肉、肠壁及肠内容物中已可测得很高的病毒滴度,并一直保持至第8天(除血液外);其中以腦及肌肉中之病毒滴度为最高(10~(-7))。Boring氏亦发现乳鼠在感染后,病毒很快地分布于其血、腦、肝、胰、及肌肉中,其病毒滴度则以感染后的第二天为最高。
Studying the distribution and pathological changes of Coxsachie virus in infected neonatal rats can reveal the pathogenesis of this virus in neonatal rats. In addition, its pathological changes in neonatal rats can also help to diagnose the disease caused by human beings . Melnick and Godman’s and other offspring were infected intraperitoneally with Coxsachie B-1 virus from 4 to 5 days after birth and found that in their blood, brain, heart, liver, muscle, intestine and intestine The virus had a measurable virus titre in the contents and remained on day 8 (except blood); the virus titer in brain and muscle was the highest (10 -7). Boring’s also found that after infection, the virus rapidly distributed in the blood, brain, liver, pancreas, and muscle and the virus titer was highest on the second day after infection.