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目的：全氨啉是从海洋生物中提取的一种生物碱研究发现其具良好镇痛作用。为了解全氨啉的致突变作用，按新药申报审批要求对其进行试验。方法：采用Ａｍｅｓ试验，最高剂量达到５ｍｇ／皿，设五个剂量组，加和不加Ｓ９同时进行，结果是两次６皿均值；ＣＨＬ细胞体外染色体畸变
Objective: Ammoniacal is an alkaloid extracted from marine organisms and found that it has a good analgesic effect. In order to understand the mutagenicity of all-aminopyrine, it is tested according to the requirement of approval of new drug application. Methods: Ames test, the highest dose of 5mg / dish, set up five doses, with and without S9 simultaneously, the result is twice the average of 6 dishes; CHL cells in vitro chromosomal aberrations