论文部分内容阅读
目的 :探讨胃肝样腺癌的病理组织学特点及生物学行为。方法 :分析经手术及病理证实的胃肝样腺癌 11例 ,并应用免疫组化染色及电镜观察。结果 :胃肝样腺癌 ,光镜下最具特征的组织学表现为玻璃样小体、广泛性侵犯静脉 ;免疫组化AFP、AAT、ACT阳性 ,HCG阴性 ;电镜下 ,可见癌细胞围成腔样 ,类似于毛细胆管结构 ,腔面有微绒毛 ,细胞膜相连处有连接复合体。随访 1～ 5年 ,死亡 6例 ,其中 5例死于胃肝样腺癌广泛转移 ,1例死于腹腔种植性转移。其余随访中均存活。结论 :胃肝样腺癌是原发于胃粘膜并具有腺癌和肝细胞癌特征的一种胃癌 ,分化差 ,易肝转移 ,预后不良
Objective: To investigate the histopathological features and biological behaviors of hepatocellular adenocarcinoma. Methods : Analysis of 11 cases of gastric hepatoid adenocarcinoma confirmed by surgery and pathology. Immunohistochemical staining and electron microscopy were performed. Results: Gastric hepatoid adenocarcinoma, the most characteristic histological appearance under light microscope was vitreous-like bodies, extensive invasion of veins; immunohistochemistry AFP, AAT, ACT positive, HCG negative; electron microscopy, visible cancer cells surrounded Cavity-like, similar to capillary bile duct structures, with microvilli on the cavity surface, with connecting complexes at the cell membrane junctions. During 1 to 5 years of follow-up, 6 patients died. Five of them died of extensive metastasis of gastric hepatoid adenocarcinoma, and one died of abdominal implant metastasis. All other visits survived. Conclusion : Gastric hepatoid adenocarcinoma is a kind of gastric cancer with primary features of adenocarcinoma and hepatocellular carcinoma. It is poorly differentiated, easy to metastasize, and has poor prognosis.