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目的 :探讨温补肾阳方防治骨质疏松症的机理。方法 :以卵巢切除所致的骨质疏松大鼠为模型 ,采用骨组织形态计量学方法测定胫骨 TBV%、TRS%和 TFS% ,分别采用小鼠胸腺细胞检测法和依赖株细胞增殖反应检测法测定 IL- 1和 IL- 6的活性。结果 :温补肾阳方能使胫骨 TBV%显著增高 ,使 TRS%和TFS%均显著降低 ,并能使之降低到与正常大鼠相当的水平。大鼠切除卵巢后 ,IL- 1和 IL - 6活性显著增高 ,而温补肾阳方对这两者均有明显的抑制作用。结论 :温补肾阳方能够抑制 IL- 1、IL- 6的活性是其防治绝经后骨质疏松症的机理之一。
Objective : To explore the mechanism of prevention and treatment of osteoporosis by Wen Bushen Yang Yang. METHODS: Osteoporosis in ovariectomized rats was used as a model. Bone histomorphometry was used to determine TBV%, TRS%, and TFS%. Mouse thymocyte assay and dependent cell proliferation assay were used. The activity of IL-1 and IL-6 was measured. Results: Warming and tonifying kidney can significantly increase the tibial TBV%, and significantly reduce the TRS% and TFS%, and can reduce it to a level comparable to that of normal rats. After the ovariectomy in rats, the activity of IL-1 and IL-6 was significantly increased, while Wen-Bu Shen Yang Decoction had obvious inhibitory effects on both of them. Conclusion : Wen Bing Shen Yang Fang can inhibit the activity of IL-1 and IL-6 is one of the mechanisms of prevention and treatment of postmenopausal osteoporosis.