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Five novel pterocarpan derivatives (1-5) and three known pterocarpans were isolated from the roots of Sophoraflavescens Ait.Their structures were elucidated based on extensive spectroscopic data (UV,IR,1D and 2D NMR,and HR-ESI-MS).Notably,compounds 1-5 were the first reported natural products,which possess unique pterocarpan-glucose-long chain aliphatic acid structures.The kinds of aliphatic acids were determined by comparison with authentic aliphatic acids using HPLC-ELSD analysis after acid hydrolysis.The ab-solute configurations of 1-5 were Confirmed by analysis of their ECD spectra.All compounds were evaluated against lipopolysaccha-ride (LPS)-induced TNF-α production in RAW264.7 cells,and compound 1 showed significant inhibitory activity with inhibition rate of 86.22％,IC50 =0.79 μmol/L (dexamethasone as positive control,inhibition rate of 71.38％).