【摘 要】
：
An HPLC-UV-guided separation was performed and four pairs of unprecedented macathiohydantoin dimers,lepithiohydimerins A-D(1-4) bearing a rare disulfide bond were isolated from the tubers of Maca.Their structures were unambiguously confirmed by NMR spectr
【机 构】
：
State Key Laboratory of Phytochemistry and Plant Resources in West China,Kunming Institute of Botany
论文部分内容阅读
An HPLC-UV-guided separation was performed and four pairs of unprecedented macathiohydantoin dimers,lepithiohydimerins A-D(1-4) bearing a rare disulfide bond were isolated from the tubers of Maca.Their structures were unambiguously confirmed by NMR spectroscopic,X-ray crystallographic and electronic circular dichroism (ECD) analyses.At the concentration of 20 μmol/L,compounds 2-1,2-2,and 4-1 increased the viability of PC12 cells with the cell viability at (72.06 ± 1.14)％,(72.64 ± 1.49)％,and (70.93 ± 1.22)％,respectively.Furthermore,the serial concentration experiment showed that they can protect PC12 cells in a dose-dependent manner.
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