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目的了解慢性心力衰竭(CHF)患者不同心功能等级与血清中糖类抗原125(CA125)表达水平的关系,CA125升高与临床特征相关性。方法 164例CHF患者入院时检测CA125、心肌肌钙蛋白-I(Tn I)、B型脑钠肽(BNP)和C反应蛋白(CRP)以及X线胸片、心电图、超声心动图检查,按照纽约心脏协会(NYHA)心功能分级标准分为2级组、3级组、4级组;根据CA125水平分为正常组(CA125≤35 U/ml)和升高组(CA125>35 U/ml)。并设32例健康体检者为正常对照组。结果各心功能组CHF患者CA125水平高于对照组,心功能组2级<3级<4级,各组间差异有统计学意义(P<0.05);升高组与正常组相比,BNP、Tn I、CRP结果明显升高(P<0.05),出现胸腔积液、心包积液、肺部感染的比率也明显增加(P<0.05),但与年龄、性别、糖尿病、高血压、肾功能不全、LVEF不相关。结论随着CHF患者心衰程度加重,CA125表达水平更高,是评价心功能的敏感指标。
Objective To investigate the relationship between different levels of cardiac function and the level of carbohydrate antigen 125 (CA125) in patients with chronic heart failure (CHF) and the correlation between the elevation of CA125 and clinical features. Methods One hundred and sixty-four patients with CHF were enrolled in the study. The levels of CA125, Tn I, BNP and C-reactive protein (CRP) and X-ray, electrocardiogram and echocardiography were measured. The New York Heart Association (NYHA) cardiac function grading standards were divided into 2 groups, 3 groups and 4 groups. According to CA125 level, they were divided into normal group (CA125≤35 U / ml) and elevated group (CA125> 35 U / ml ). And set 32 cases of healthy people as the normal control group. Results Compared with the control group, the level of CA125 in heart function group was significantly higher than that in the control group, and the level of cardiac function group was lower than that in the control group (P <0.05). There was significant difference between the two groups (P <0.05). The rates of pleural effusion, pericardial effusion and pulmonary infection also increased significantly (P <0.05), but not with age, sex, diabetes, hypertension, renal Incomplete, LVEF not relevant. Conclusions With the worsening of heart failure in CHF patients, the expression of CA125 is higher, which is a sensitive index to evaluate cardiac function.