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目的 探讨放射治疗同时配合DF方案化疗对食管癌的治疗意义。方法 将 130例食管癌患者随机分为 2个组进行前瞻性临床研究。一组 6 5例行放射治疗同时配合DF方案化疗 (综合组 ) ,另一组 6 5例行单纯放射治疗 (单放组 )。放射治疗采用 6MV -X线照射 ,DT6 0 - 6 6GY ;化疗在放射治疗开始第二周进行 ,每周一次。共进行 3～ 4次。结果 全部病例随访 3年以上 ,综合组与单放组 1,2 ,3年生存率分别为 6 4 .6 %、4 6 .2 %、33.8%和 4 4 .6 %、2 7.7%、16 .9% ,综合组 1、2、3年生存率明显优于单放组 (P <0 .0 5 ) ,且无严重毒副反应发生 ,远地转移率综合组明显低于单放组 (P <0 .0 5 )。结论 放射治疗食管癌同时配合DF方案化疗 ,能减少远地转移提高生存率 ,是值得临床进一步探讨的治疗方法
Objective To investigate the therapeutic effect of radiotherapy combined with DF chemotherapy on esophageal cancer. Methods 130 patients with esophageal cancer were randomly divided into two groups for prospective clinical study. A group of 65 routine radiotherapy combined with DF chemotherapy (integrated group), and the other 65 cases of simple radiotherapy (radiotherapy group). Radiation therapy using 6MV-X line irradiation, DT6 0-6 6GY; chemotherapy in the second week after the start of radiotherapy, once a week. A total of 3 to 4 times. Results All patients were followed up for more than 3 years. The 1, 2, 3-year survival rates of the combined group and the single group were respectively 6.46%, 46.2%, 33.8% and 44.6%, 27.7%, 16 .9%. The 1, 2, 3-year survival rate of the comprehensive group was significantly better than that of the single group (P <0.05), and no serious side effects were found. The far- P <0. 05). Conclusion Radiotherapy of esophageal cancer combined with DF regimen chemotherapy can reduce the distant metastasis and improve survival rate, is worth further clinical treatment