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利用室温离子液体作催化剂 ,芳香醛、尿素和乙酰乙酸乙酯或乙酰丙酮三组分缩合制备 3,4 二氢嘧啶 2 酮衍生物 ,反应条件温和 ,反应时间短 ,且不需另加有机溶剂 .考察了不同取代基对芳香醛、尿素和乙酰乙酸乙酯或乙酰丙酮三组分缩合反应的影响 .还考察了不同的室温离子液体的催化性能 ,发现 1 丁基 3 甲基咪唑六氟磷酸盐较1 丁基 3 甲基咪唑四氟硼酸盐的催化效果略好
Using room temperature ionic liquid as catalyst, aromatic dihydric aldehyde, urea and ethyl acetoacetate or acetylacetone three component condensation of 3,4-dihydropyrimidine 2 ketone derivatives, mild reaction conditions, the reaction time is short, and without additional organic solvents The effects of different substituents on the condensation reaction of aromatic aldehydes, urea and ethyl acetoacetate or acetylacetone three components were investigated.The catalytic properties of different ionic liquids at room temperature were also investigated and it was found that 1-butyl-3-methylimidazolium hexafluorophosphate Salt than 1 butyl 3 methyl imidazole tetrafluoroborate catalytic effect is slightly better