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G protein-coupled receptor 119 (GPR119),encoded by human GPR119 gene,is considered as a novel member of cannabinoid receptors.GPR119 is expressed predominantly in the pancreas and gastrointestinal tract of rodents and humans,as well as in the brain of rodents.GPR119 has also been shown to regulate incretin and insulin hormone secretion.Activation of GPR119 causes a reduc-tion in food intake and lowers gain of body weight in rats [1].Targeting GPR119 with specific agonists has thus been attempted as a novel strategy to treat obesity and diabetes [2-4].In addition,GPR119 also plays an important role in bone metabolism,thus making GPR119 a potential target for bone resorption-associated diseases [5].