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Blast lung injury(BLI)is the major cause of death in explosion-derived shock waves;however,the mechanisms of BLI are not well understood.To identify the time-dependent manner of BLI,a model oflung injury of rats induced by shockwaves was established by a fuel air explosive.The model was evaluated by hematoxylin and eosin staining and pathological score.The inflammation and oxida-tive stress of lung injury were also investigated.The pathological scores of rats'lung injury at 2 h,24 h,3 days,and 7 days post-blast were 9.75±2.96,13.00±1.85,8.50±1.51,and 4.00±1.41,respec-tively,which were significantly increased compared with those in the control group(1.13±0.64;P＜0.05).The respiratory frequency and pause were increased significantly,while minute expiratory volume,inspiratory time,and inspiratory peak flow rate were decreased in a time-dependent man-ner at 2 and 24 h post-blast compared with those in the control group.In addition,the expressions of inflammatory factors such as interleukin(IL)-6,IL-8,FosB,and NF-kB were increased signifi-cantly at 2 h and peaked at 24 h,which gradually decreased after 3 days and returned to normal in 2 weeks.The levels of total antioxidant capacity,total superoxide dismutase,and glutathione peroxidase were significantly decreased 24 h after the shock wave blast.Conversely,the malondi-aldehyde level reached the peak at 24 h.These results indicated that inflammatory and oxidative stress induced by shock waves changed significantly in a time-dependent manner,which may be the important factors and novel therapeutic targets for the treatment of BLI.