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将慢性肾病伴早期肾衰竭(肌酐清除率30 ml/min左右)病人分成条件相似的两组,作为研究肾衰竭发展速度的对象。两组饮食中的热卡相等(约35kcal/kg/d),蛋白同样限制(约0.6g/kg/d)。第1组29人,磷摄入极低(6.5 mg/kg/d)(可选用鸡蛋白、淀粉以及反复煮沸并换水的食物);第2组26人,磷摄入较高(12mg/kg/d)。两组由自由饮食转到控制饮食后,肌酐清除率的减低均变慢:第1组每月平均减低由0.9±0.67转到0.07±0.38ml/min,第2组由0.79±0.53转到0.55±0.43,第1组的这种改变较第2组明显得多。第2组血清磷酸盐、尿磷酸盐24小时排出量/肌酐清除率,以及血清甲状旁腺激素的平均水平均增高,而第1组除尿磷酸盐/肌酐清除率接近正常外,余两者均正常,表明第2组肾衰竭速度
Patients with chronic kidney disease and early renal failure (creatinine clearance of 30 ml / min or so) were divided into two groups with similar conditions as subjects for studying the rate of development of renal failure. The calories in both diets were equal (about 35 kcal / kg / d), with the same protein limit (about 0.6 g / kg / d). In Group 1, phosphorus intake was very low (6.5 mg / kg / d) (egg white, starch, and food boiling and changing again); Group 2, with a higher phosphorus intake (12 mg / kg / d). The decrease in creatinine clearance was slower in both groups from free diet to control diet: the monthly mean decrease in group 1 was from 0.9 ± 0.67 to 0.07 ± 0.38 ml / min in group 2, and from 0.79 ± 0.53 to 0.55 in group 2 ± 0.43, the first group of such changes than the second group was significantly more. Group 2 serum phosphate, urinary phosphate excretion / creatinine clearance, and serum parathyroid hormone average levels were increased, while the first group in addition to urinary phosphate / creatinine clearance rate close to normal, the remaining two All were normal, indicating that the second group renal failure rate