Demonstration of three dopamine molecules bound to <i>α</i>-Synuclein: I

• 作 者: Sakurako Shimotakahara Yuuki S
• 机 构: ChemicalAnalysisCenter,DepartmentofChemistry,DepartmentofDementiaandHigherBrainFunction,SchoolofLife
• 出 处: 生物物理化学(英文)
• 发表日期: 2012年2期
• 关键词: α-Synuclein DOPAMINE FIBRILLATION OLIGOMERIZATION Mass Spectrometry α-Synuclein

α-Synuclein is the major component of the filamentous Lewy bodies and Lewy neurites that define neuropathological features and dementia with Lewy bodies. To investigate the role of dopamine (DA) in α-synuclein fibrillation, the structural propensities to