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目的探讨主动脉组织Toll样受体4(TLR4)蛋白表达与动脉粥样硬化发病机制及冠状动脉病变的关系。方法 42例冠状动脉旁路移植术(CABG)打孔时废弃主动脉组织为研究组,10名肾移植供体者的动脉组织为对照组。应用免疫组化法检测动脉组织细胞中TLR4蛋白表达,分析其与冠状动脉造影显示的冠状动脉病变的关系。结果研究组主动脉组织TLR4蛋白表达显著,而对照组TLR4蛋白无表达(P<0.01);主动脉组织TLR4蛋白表达量与冠状动脉粥样硬化的病变程度密切相关(P<0.01)。结论 TLR4的高表达表明动脉粥样硬化斑块内炎性反应明显;利用CABG打孔时主动脉组织作为样本,为研究动脉粥样硬化发病机制及干预靶点等提供了新的方法和途径。
Objective To investigate the relationship between the expression of Toll-like receptor 4 (TLR4) and the pathogenesis of atherosclerosis and coronary artery disease in aorta. Methods 42 cases of coronary artery bypass grafting (CABG) when the hole was punctured aorta tissue for the study group, 10 renal transplant donor arteries as the control group. The expression of TLR4 protein in artery tissue was detected by immunohistochemistry and the relationship between TLR4 protein expression and coronary artery lesions showed by coronary angiography. Results The expression of TLR4 protein in the aorta tissue was significant in the study group, but not in the control group (P <0.01). The TLR4 protein expression in the aorta was closely related to the severity of coronary atherosclerosis (P <0.01). Conclusion The high expression of TLR4 indicates that the inflammatory reaction in atherosclerotic plaques is obvious. Using the aorta tissue of CABG as a sample, it provides a new method and approach for studying the pathogenesis of atherosclerosis and the target of intervention.