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背景:研究表明,CD44的表达与胃癌恶性转化具有密切联系。目的:分析肿瘤干细胞表面标志物CD44在胃癌组织中的表达及其临床意义。方法:对92例胃癌患者的术后癌组织标本及30例经病理检查证实为正常胃组织标本进行免疫组化(S-P法)检测,比较两种组织中CD44蛋白的阳性表达率差异,并分析CD44表达与患者预后的关系。结果与结论:(1)胃癌组CD44蛋白的阳性表达率(73%)显著高于正常组(3%),差异有显著性意义(P<0.05);(2)胃癌组CD44蛋白的阳性表达率与患者的临床TNM分期、分化程度、浸润深度、淋巴结转移有显著关系(P<0.05);(3)胃癌组CD44蛋白阳性表达患者3年存活率(37%)显著低于阴性表达患者(64%),差异有显著性意义(P<0.05);(4)TNM分期越高、分化程度越低、淋巴结转移、CD44阳性表达是胃癌患者的独立危险因素(P<0.05),其异常持续性阳性表达可以在一定程度上提示胃癌患者预后不良。
Background: Studies have shown that CD44 expression is closely related to malignant transformation of gastric cancer. Objective: To analyze the expression of tumor stem cell surface marker CD44 in gastric carcinoma and its clinical significance. Methods: Tumor specimens of 92 patients with gastric cancer and 30 specimens of normal gastric tissue confirmed by pathology were detected by immunohistochemistry (SP method). The differences of the positive expression rates of CD44 protein between the two tissues were analyzed and analyzed Relationship between the expression of CD44 and the prognosis of patients. RESULTS AND CONCLUSION: (1) The positive rate of CD44 protein in gastric cancer group (73%) was significantly higher than that in normal group (3%) (P <0.05). (2) The positive expression of CD44 protein (3) The 3-year survival rate (37%) of patients with positive expression of CD44 protein in gastric cancer was significantly lower than that of patients with negative expression (0%, P <0.05) 64%, respectively) (P <0.05). (4) The higher TNM stage, the lower the degree of differentiation, lymph node metastasis and CD44 positive expression were independent risk factors of gastric cancer (P <0.05) Sex-positive expression can prompt gastric cancer patients to some extent, poor prognosis.