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紫外线(UV)不仅具有致癌活性,还能改变某些免疫反应。作者就用UV照射小鼠引起的免疫学改变,包括局部和远隔的作用,复习了有关文献。 UV照射对免疫功能的局部作用关于UV照射引起局部免疫反应的改变,最近已集中于UV照射在接触过敏反应(CHS)诱导期作用的研究。Toews等报道,用亚红斑量UV照射小鼠后,在照射部位皮肤外涂DNFB,仅产生轻微的CHS反应。另外,通过照射部位皮肤进行致敏,可导致特异免疫耐受性的诱导和出现抗原特异性T抑制细胞(Ts)。UV照射引起免疫改变与照射部位皮肤郎格罕细胞数量减少和形态改变有关,提示Ts途径的激活作用可能是由于UV照射直接作用于抗原呈递细胞所致。支持此假说的实验证明,应用与抗原结合前的在体外经UV照射的表皮细胞来免疫小鼠,可激活Ts途径。Granstein等最近提出,在表皮
Ultraviolet (UV) not only has oncogenic activity, but also changes certain immune responses. The authors reviewed the literature on immunological changes induced by UV irradiation in mice, both locally and remotely. Local Effects of UV Irradiation on Immune Function Recent changes in the local immune response to UV irradiation have focused on the role of UV irradiation in the induction of hypersensitive response (CHS). Toews et al reported that subcutaneous erythema UV irradiation mice, the outer part of the skin irradiated with DNFB, only a slight CHS reaction. In addition, sensitization by irradiation of the skin of the part leads to the induction of specific immune tolerance and the appearance of antigen-specific T suppressor cells (Ts). The immunological changes induced by UV irradiation were related to the decrease of the number of Langerhans cells and the morphological changes in the irradiated part of the skin, suggesting that the activation of the Ts pathway may be caused by the direct action of UV irradiation on the antigen-presenting cells. Experiments supporting this hypothesis have demonstrated that the Ts pathway can be activated by immunizing mice with UV-irradiated epidermal cells in vitro prior to antigen binding. Granstein et al. Recently proposed in the epidermis