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目的探讨肝素钙辅助治疗婴幼儿哮喘的效果。方法哮喘患儿68例随机分为对照组和治疗组,前者常规抗炎、平喘和对症治疗,后者在此基础上加用肝素钙静脉滴注。治疗前、后进行血小板计数,并检测患儿活化部分凝血活酶时间(APTT),D-二聚体(D-limer),血清抗体IgE,IgA1和IgA2。结果治疗组和对照组的总有效率依次为88.9%和62.5%,差异有非常显著性(P<0.01)。与治疗前相比,治疗后治疗组患儿血小板计数(BPC)平均下降288×109/L,APTT水平平均上升9.65s,D-limer水平平均下降0.31mg/L,差异具有非常显著性(P<0.01);治疗后治疗组患儿血清IgE平均下降116.7mg/L,IgA1升高1751。1mg/L,IgA2升高54.9mg/L,差异均有非常显著性(P<0.01)。结论肝素钙辅助治疗婴幼儿哮喘效果较好,其可缓解高凝状态,改善患儿免疫功能。
Objective To investigate the effect of heparin calcium in the treatment of infant asthma. Methods Sixty-eight children with asthma were randomly divided into control group and treatment group. The former received routine anti-inflammatory, antiasthmatic and symptomatic treatment, and the latter received heparin calcium intravenous infusion. Platelet counts were taken before and after treatment. Activated partial thromboplastin time (APTT), D-dimer, serum antibodies IgE, IgA1 and IgA2 were measured in children. Results The total effective rates of the treatment group and the control group were 88.9% and 62.5%, respectively, with significant differences (P <0.01). Compared with those before treatment, the mean value of platelet count (BPC) in treatment group decreased by 288 × 109 / L, APTT level increased by 9.65s, and D-limer level decreased by 0.31mg / L, the difference was significant (P <0.01). After treatment, serum IgE level in treatment group decreased by 116.7mg / L, IgA1 increased by 1751.1mg / L, IgA2 increased by 54.9mg / L, the difference was significant (P <0.01). Conclusion Heparin calcium adjuvant treatment of infant asthma is better, which can alleviate hypercoagulable state, improve immune function in children.