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目的探讨患者移植造血干细胞期间成分输血的治疗效果及可能的影响因素。方法对75名行造血干细胞移植术的白血病患者,通过计算输注血小板后24 h的血小板回升率、校正血小板增高指数值的变化以及输注悬浮红细胞后24 h内血红蛋白的增加量,观察其临床症状的改善,判断输注后的效果。观察性别,移植前、后,供受者血型是否相符等不同因素对悬浮红细胞、机采血小板输注效果的影响。结果白血病患者造血干细胞移植后血小板输注效果优于移植前输注(61.91%vs55.77%,P<0.05),而红细胞输注效果移植前优于移植后(71.43%vs47.91%,P<0.01);供受者血型相同血小板和红细胞输注效果都优于血型不同者(分别为70.00%vs55.77%、58.00%vs40.00%,P<0.05)。结论造血干细胞移植前后输注、造血干细胞供受者血型相符与否是影响移植患者悬浮红细胞、机采血小板输注效果的主要因素。
Objective To investigate the therapeutic effect and possible influencing factors of transfusion of blood components during the transplantation of hematopoietic stem cells in patients. Methods A total of 75 leukemia patients undergoing hematopoietic stem cell transplantation were enrolled in this study. The changes of platelet reuptake rate at 24 h after transfusion of platelets, the change of platelet index and the increase of hemoglobin within 24 h after transfusion of erythrocytes were observed. Symptoms improve, to determine the effect of infusion. The effects of different factors such as gender, pre-transplant and post-transplant donor-recipient blood type on the transfusion efficiency of suspended red blood cells and platelet-collecting platelets were observed. Results The platelet transfusion after leukemia hematopoietic stem cell transplantation was better than that before transplantation (61.91% vs 55.77%, P <0.05), while the transfusion efficiency of erythrocyte was better than that after transplantation (71.43% vs 47.91%, P <0.01). The effect of blood platelet and erythrocyte infusion on recipients was better than that of blood group (70.00% vs55.77%, 58.00% vs40.00%, P <0.05 respectively). Conclusion Before and after transplantation of hematopoietic stem cell transplantation, whether hematopoietic stem cell donor blood type matches or not is the main factor that affects the transfusion efficiency of suspended red blood cells and platelet in transplant patients.