流动注射分析法测定片剂中磺胺甲基异噁唑含量的研究

• 作 者: 郭涛 马艳 史国兵 李淑珍 孙毓庆 毕森林 胡立民
• 机 构: 沈阳军区总医院药剂科,沈阳军区司令部门诊部药局,沈阳药学院应用化学研究所,沈阳军区卫生部药品检验所,
• 出 处: 中国药学杂志
• 发表日期: 1990年08期
• 关键词: 磺胺甲基异噁唑 流动注射分析法 样品测定结果 流动注射分析仪 对照品 药典法 甲氧 含量测定 干扰因素 自动电位滴定仪

本文应用流动注射分析(flow injection analysis)法对片剂中磺胺甲基异噁唑含量测定的条件、方法和干扰因素进行了研究。并对国内5个药厂生产的复方磺胺甲基异噁唑片予以测定。实验结果表明,本法不受赋形剂和甲氧苄胺嘧啶的干扰,灵敏度高,简便快速,用样品量少,重现性好,平均回收率为100.2%,CV为±l.02%,样品测定结果与中国药典法接近。

In this paper, flow injection analysis (flow injection analysis) method for the determination of sulfamethoxazole tablets content of the conditions, methods and interference factors were studied. And 5 domestic pharmaceutical production compound sulfamethoxazole tablets were measured. The experimental results show that this method is not affected by the excipients and trimethoprim, high sensitivity, simple and rapid, with less sample size, good reproducibility, the average recovery was 100.2%, CV was ± l.02% , The results of the sample and the Chinese Pharmacopoeia close.