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本文将23名急性心肌梗塞(AMI)、4名陈旧性心肌梗塞(OMI)和9名心绞痛惠者随机分为肝素组和对照组。两组除肝素外其它治疗基本相同,观察小剂量肝素对血清超氧化物歧化酶(SOD)和过氧化脂质(LPO)及其它指标的影响。结果表明,小剂量肝素能在不影响出凝血和凝血酶元时间、血小板计数和血小板聚集试验的情况下,提高血清SOD水平,降低血清LPO浓度,减少心绞痛发作次数,说明小剂量肝素具有保护缺血心肌和清除自由基作用。此外,作者还简述自由基,尤其是氧自由基与心肌缺血和心肌梗塞的病理过程的关系。
In this paper, 23 acute myocardial infarction (AMI), 4 old myocardial infarction (OMI) and 9 patients with angina benefit were randomly divided into heparin group and control group. Except heparin, the other two treatments were basically the same. The effect of low dose heparin on serum superoxide dismutase (SOD) and lipid peroxidation (LPO) and other indexes were observed. The results showed that low-dose heparin can increase serum SOD level, reduce serum LPO concentration and reduce the number of angina attacks without affecting the coagulation and thrombin time, platelet count and platelet aggregation test, indicating that low-dose heparin has protection Blood and eliminate free radical role. In addition, the authors also briefly describe the relationship between free radicals, especially oxygen free radicals, and the pathological processes of myocardial ischemia and myocardial infarction.