绝经后妇女结直肠癌风险与膳食炎症指数间的关系:妇女健康倡议的结果

• 作 者: 徐菁
• 机 构: 四川大学华西临床学院,
• 出 处: 中国普外基础与临床杂志
• 发表日期: 2015年07期
• 关键词: 结直肠癌 膳食 置信区间 炎症 结肠癌 近端结肠 远端结肠 随访过程 中起 验证研究

炎症在结直肠癌的发生中起重要作用。本研究利用妇女健康倡议中评价饮食炎症潜力的膳食炎症指数前瞻性地评估绝经后妇女结直肠癌风险与该指标的关系。结果发现:在平均11.3年的随访过程中,共确诊1 920例结直肠癌(1 559例结肠癌和361例直肠癌)。高膳食炎症指数与结直肠癌的高发生率相关(HR=1.22,95%置信区间为1.05~1.43,P=0.02),且与近端结肠癌的高发生率相关(HR=1.35,95%置信区间为1.05~1.67,P=0.01);但与远端结肠癌和直肠癌的发生率无明显关系。因

Inflammation plays an important role in the development of colorectal cancer. The present study used the Dietary Index of Inflammation (CPI) in women’s health initiative to evaluate the potential of dietary inflammation to prospectively assess the association between the risk of colorectal cancer and the risk of postmenopausal women. A total of 1 920 colorectal cancers (1 559 colon and 361 rectal cancers) were diagnosed during an average of 11.3 years of follow-up. The high dietary inflammation index was associated with a high incidence of colorectal cancer (HR = 1.22, 95% confidence interval 1.05-1.43, P = 0.02) and was associated with a high incidence of proximal colon cancer (HR = 1.35, 95% Confidence interval ranged from 1.05 to 1.67, P = 0.01). However, there was no significant correlation between the incidence of distal colon cancer and rectal cancer. because