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目的研究稳定期慢性阻塞性肺疾病(慢阻肺)患者血清中炎性因子、肌肉抑制素、第一秒用力呼气容积占预计值的百分比(FEV1%pred)、体重指数(BMI)情况及相关性。方法选择2010-2012年重庆市稳定期慢阻肺男性患者及年龄相仿的健康者,用酶联免疫吸附法测定血清肿瘤坏死因子(TNF)-α、白介素(IL)-6、肌肉抑制素;肺功能仪器检测每位受试者的FEV1%pred;测定身高及体重,计算BMI。慢阻肺患者分别根据FEV1%pred及BMI分组,比较慢阻肺患者与健康受试者相关指标,探讨血清炎症因子、FEV1%预计值与肌肉抑制素的相关性。结果根据FEV1%pred及BMI分组(F组/T组)的慢阻肺组患者血清中TNF-α、IL-6及肌肉抑制素水平较对照组均有升高,除F1组/T1组外,差异有统计学意义(P<0.01),肺功能越差,BMI越低,TNF-α、IL-6及肌肉抑制素水平越高(P<0.05)。TNF-α、IL-6与肌肉抑制素正相关(P<0.05),FEV1%pred与肌肉抑制素负相关(P<0.05)。结论慢阻肺患者肺功能越差,BMI越低者,炎性因子及肌肉抑制素水平越高;炎性因子水平越高者,肌肉抑制素水平越高;肌肉抑制素水平越高者,反应肌肉萎缩越严重,肺功能越差,病情越重。炎性因子及肌肉抑制素可能成为慢阻肺患者潜在治疗的靶点。
Objective To investigate the relationship between the levels of inflammatory cytokines, the percentage of first-second forced expiratory volume (FEV1% pred) and body mass index (BMI) in patients with stable chronic obstructive pulmonary disease (COPD) Correlation. Methods The serum level of TNF - α, IL - 6 and myostatin in serum of chronic obstructive pulmonary disease (COPD) patients and healthy people of similar ages from 2010 to 2012 in Chongqing were determined by enzyme linked immunosorbent assay. Pulmonary function tests for each subject’s FEV1% pred; measured height and weight, calculate the BMI. COPD patients were divided into groups based on FEV1% pred and BMI, and the indexes of COPD patients and healthy subjects were compared to explore the correlation between serum inflammatory factors, FEV1% predictive value and myostatin. Results The level of TNF-α, IL-6 and myostatin in serum of COPD patients with FEV1% pred and BMI group (F group / T group) were higher than that of the control group except F1 group and T1 group , The difference was statistically significant (P <0.01). The worse the lung function, the lower the BMI, the higher the levels of TNF-α, IL-6 and myostatin (P <0.05). TNF-α, IL-6 were positively correlated with myostatin (P <0.05), and FEV1% pred with myostatin negatively correlated (P <0.05). Conclusions The lung function of patients with COPD is poorer. The lower the BMI, the higher the level of inflammatory cytokin and inflammatory cytokines. The higher the level of inflammatory cytokines is, the higher the content of myostatin. The higher the level of myostatin is, The more severe muscle atrophy, the worse the lung function, the more serious the disease. Inflammatory factors and myostatin may be potential targets for COPD patients.