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本研究观察了大鼠急性心肌梗塞（ＡＭＩ）早期血浆内皮素（ＥＴ）与血液流变学的变化及卡托普利对其影响。结果显示，ＡＭＩ后６ｈ血浆ＥＴ水平显著升高，血液流变学明显异常；卡托普利治疗能明显抑制ＥＴ的增高，改善血液流变性，缩小心肌梗塞范围。提示ＥＴ及血液流变学的早期改变在ＡＭＩ后的病理生理中可能有重要作用，卡托普利降低ＡＭＩ早期血浆ＥＴ水平，改善血液流变性，可能是其治疗ＡＭＩ作用机制之一。
This study investigated the changes of early plasma endothelin (ET) and hemorrheology in rats with acute myocardial infarction (AMI) and the effects of captopril on it. The results showed that at 6h after AMI, the plasma ET level increased significantly and the hemorrheology was abnormal. Captopril treatment could significantly inhibit the increase of ET, improve the blood rheology and reduce the range of myocardial infarction. It is suggested that the early changes of ET and hemorheology may play an important role in the pathophysiology after AMI. Captopril may reduce the level of ET in the early stage of AMI and improve the hemorrheology, which may be one of the mechanisms of AMI treatment.