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牙本质龋的形成明显包含两个方面,一是细菌产酸脱矿,二是牙本质有机物的分解破坏,根据作者以前的研究发现,在牙本质龋中存在有多种蛋白水解酶及多糖水解酶的活性,包括胶原水解酶,从而推论,牙本质有机物在龋齿形成中的破坏过程是一种细菌酶的酶解过程,而这种有机物的酶解又为细菌的进一步侵入提供了营养来源,根据这样一种设想,我们选了细菌糖代谢中的三种脱氢酶,乳酸脱氢酶、琥珀酸脱氢酶和谷氨酸脱氢酶,进行组织化学定位研究,以推测细菌在牙本质龋形成中的营养和代谢过程,与以前的研究结合起来,证明牙本质有机物
The formation of dentine caries obviously contains two aspects, one is the acid-producing bacteria demineralization, the second is the decomposition of dentin organic destruction, according to the author's previous study found that in the dentine caries there are a variety of proteolytic enzymes and polysaccharide hydrolysis Enzyme activity, including collagen hydrolase, deduces that the destruction of dentin organic matter in the formation of dental caries is a bacterial enzyme enzymatic hydrolysis, which in turn provides a source of nutrients for further bacterial invasion, Based on such an assumption, we selected three kinds of dehydrogenase, lactate dehydrogenase, succinate dehydrogenase and glutamate dehydrogenase in bacterial glucose metabolism for histochemical localization studies to speculate bacteria in the dentin Nutritional and metabolic processes in cariogenesis, combined with previous studies, demonstrate that dentin organics