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Objective:To observe the clinical therapeutic effect of ginger-isolated moxibustion on cancer-related fa-tigue(CRF)in the patients with gastric cancer.rnMethods:The patients in the conventional treatment group accepted conventional chemotherapy.In the ginger-isolated moxibustion group,on the base of the conventional chemotherapy,ginger-isolated moxi-bustion was added at Shénquè(神阙CV8),Shàngwǎn(上脘CV13),Zhōngwǎn(中脘CV12),Qìhǎi(气海CV6)and Guānyuán(关元CV4).Chemotherapy for 3 weeks was as 1 cycle and 2 cycles of chemotherapy were observed.rnResults:After treatment,plasma cortisol(Cor)was increased and adreno-cortico-tropic-hormone(ACTH)decreased in the ginger-isolated moxibustion group,indicating the statistical differences as compared with the levels before treatment(P ＜ 0.05),and the differences in plasma Cor and ACTH were signif-icant statistically between the two groups(P ＜ 0.05).After treatment,the score of each item of the revised fatigue scale was reduced in the ginger-isolated moxibustion group,indicating the statistical dif-ferences as compared with the score before treatment(P ＜ 0.05).The score of the revised fatigue scale was different statistically between the two groups(P ＜ 0.05).After treatment,the score of each of the items,i.e.fatigue,nausea & vomiting,pain,dyspnea,insomnia,anorexia,constipation,diarrhea and finan-cial difficulty,was reduced in the ginger-isolated moxibustion group,indicating the statistical differences as compared with the score before treatment successfully(P ＜ 0.05).The differences were significant statistically in fatigue,nausea & vomiting,pain,dyspnea,insomnia,anorexia,constipation,diarrhea and economic difficulty between the two groups(P ＜ 0.05).rnConclusion:Ginger-isolated moxibustion achieves a satisfactory effect on CRF in the patients with gastric cancer and deserves to be promoted in clinical practice.