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目的：比较５－单硝酸异山梨酯（５－ＩＳＭＮ）缓释片和普通片的相对生物利用度和药物动力学，进行相对生物利用度及药物动力学参数测定。方法：１０名男性健康受试者交叉ｐｏ给药５－ＩＳＭＮ缓释片４０ｍｇ和普通片２０ｍｇ，以硝酸异山梨酯为内标，用毛细管气相色谱－...
OBJECTIVE: To compare the relative bioavailability and pharmacokinetics of isosorbide 5-mononitrate (5-ISMN) sustained-release tablets with ordinary tablets and to determine the relative bioavailability and pharmacokinetic parameters. Methods: Ten male healthy subjects were given 10 mg of 5-ISMN sustained-release tablets and 20 mg of common tablets by crossover po, with isosorbide dinitrate as internal standard and capillary gas chromatography -...