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建立了同时测定人血清中阿西美辛和吲哚美辛的ＨＰＬＣ方法，研究了阿西美辛缓释胶囊的药代动力学。结果表明，１２ 名健康受试者口服单剂量阿西美辛缓释胶囊（９０ ｍ ｇ）时，ｔｍａｘ＝ ３．０８±１．０８ ｈ，Ｃｍａｘ＝ １．０１２±０．２８６ μｇ／ｍ ｌ，ｔ１／２（ｋｅ）＝ ８．８８４±２．０８６ ｈ，ＡＵＣ０－∞＝ ６．５２５±１．９９２ μｇ·ｈ／ｍ ｌ
A HPLC method for the simultaneous determination of acemetacin and indomethacin in human serum was established and the pharmacokinetics of acemetacin sustained-release capsules was studied. The results showed that tmax = 3.08 ± 1.08 h and Cmax = 1.012 ± 0.286 μg / m l for oral administration of a single dose of simmexinxin sustained release capsules (90 m g) in 12 healthy subjects , T1 / 2 (ke) = 8.884 ± 2.086 h, AUC0-∞ = 6.525 ± 1.992 μg · h / m l