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目的综合目前头颈部肿瘤放疗后口腔干燥治疗研究现状,分析目前口腔干燥治疗方法的优缺点以及将来研究方向。方法查询多种相关治疗资料,根据唾液分泌生理学机制和目前放射性损伤机理,分析各种治疗可能存在的缺陷,引发相关医务人员在治疗方面更好开发新的治疗方法。结果唾液的生理性分泌是完全神经反射性的,头颈部肿瘤放疗后口腔干燥涉及感受器、传入神经、传出神经、效应器损伤,目前主要针对效应器的治疗,反射弧其余部位的损伤靠自行修复,难以短时间达到应有的疗效。结论减少射野内反射弧照射剂量是有效的预防措施,已形成的口腔干燥需要针对反射弧多环节综合治疗。
Objective To summarize the current research status of oral dryness therapy in the treatment of head and neck cancer after radiotherapy and to analyze the advantages and disadvantages of the present oral dry treatment and its future research directions. Methods According to the physiological mechanism of salivary secretion and the current mechanism of radioactive injury, we analyzed the possible defects in various treatments and triggered the development of new treatment methods for the medical staff concerned. Results The physiological secretion of saliva is completely neuroreflective. The oral cavity after head and neck tumor radiotherapy involves sensory receptors, afferent nerves, afferent nerves and effector damage. At present, it is mainly aimed at the treatment of the effector and the damage of the rest of the reflex arc Rely on their own, it is difficult to achieve the desired effect in a short time. Conclusion It is an effective preventive measure to reduce the dose of intracavity reflex arc irradiation. The developed oral cavity dryness needs to be treated by multiple steps of reflex arc.