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肾小球毛细血管壁对大分子物质的通过是一个复杂而又未彻底了解的现象。多年来一直认为大分子蛋白质在尿中的出现,是由于肾小球基膜存在许多小孔,蛋白质分子比孔径小而被滤过,若蛋白分子比孔径大,则被阻止。这种单纯依孔径大小及分子大小而决定滤过与否的分子筛学说,现在已有所发展。早在1951年 Pappenheimer 等提出了分子筛学说,他们把基膜比作筛子,血浆内物质的分子越大,限制性就越增加,分子量大于血浆白蛋白分子(分子量69,000),基本
The passage of glomerular capillary walls to macromolecules is a complex and incompletely understood phenomenon. Over the years has been that macromolecular protein in the urine, is due to glomerular basement membrane there are many small pores, protein molecules smaller than the filter, if the protein molecules larger than the pore size, was blocked. This purely pore size and molecular size and decide whether to filter through the molecular sieve theory, has now been developed. As early as 1951, Pappenheimer et al. Proposed molecular sieve theory. When they compared the basement membrane to a sieve, the larger the molecules in the plasma, the more restrictive the molecular weight is greater than the plasma albumin molecule (MW 69,000)