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近年来,在临床上有不少细菌对青霉素已产生了耐药性,特别是金黄色葡萄球菌尤为严重。据统计,金黄色葡萄球菌的耐青霉素菌株已达80%以上。这种情况的存在,使青霉素的临床应用范围受到了很大限制。关于细菌产生耐药性的机制,至今尚未完全明了,主要有细菌适应能力的改变和发生变异等学说。当抗菌素作用于细菌时,细菌的某一酶系统受到破坏,因而达到抗菌效果,但经一段时间适应后,细菌的另一酶系统可起而代之,以改变代谢方式而继续生长,亦即发生了变异。另外,耐药性的产生,与菌株的不同有很大关系,不同菌株对各种抗菌素
In recent years, many bacteria have been clinically resistant to penicillin, especially Staphylococcus aureus is particularly serious. According to statistics, Staphylococcus aureus penicillin resistant strains have reached more than 80%. The existence of this situation, the clinical application of penicillin has been greatly restricted. The mechanism of bacterial resistance has not yet been completely understood, mainly the theory of bacterial adaptation and mutation. When antibiotics act on bacteria, one of the enzyme systems of the bacteria is destroyed, thus achieving an antibacterial effect, but after a period of adaptation, another enzyme system of the bacteria can take over to continue the growth by changing the metabolic mode, that is, Variation occurred. In addition, the emergence of drug resistance, and strains have a great relationship, different strains of various antibiotics