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为考察癌胚抗原（CEA）和β-2微球蛋白（β-2M）联合测定在监测大肠癌术后复发的意义。对110例大肠癌根治术后的患者定期测定CEA和β-2M，在此期间，有21例复发，其中局部复发9例，肝、肺转移9例，其他部位转移3例。CEA阳性阈值为10mg／L，β-2M为2．2mg／L。CEA敏感性为47．6％，特异性92．1％，β-2M敏感性为42．9％，特异性66．3％，CEA和β-2M联合检测，其敏感性为57．1％，CEA和β-2M在肝、肺转移的患者中敏感性较高，分别为77．8％和66．7％。提示CEA和β-2M至少能监测50％以上的术后复发的大肠癌患者，对肝肺转移敏感性高。
To investigate the significance of combined detection of carcinoembryonic antigen (CEA) and β-2 microglobulin (β-2M) in the detection of postoperative recurrence of colorectal cancer. CEA and β-2M were routinely measured in 110 patients with colorectal cancer after radical resection. During this period, 21 patients had recurrence, including 9 with local recurrence, 9 with liver and lung metastases, and 3 with other sites. The CEA positive threshold was 10 mg/L and the β-2M was 2.2 mg/L. The sensitivity of CEA was 47.6%, the specificity was 92.1%, the sensitivity of β-2M was 42.9%, the specificity was 66.3%, the combined detection of CEA and β-2M, and the sensitivity was 57.1%. The sensitivity of CEA and β-2M in patients with liver and lung metastases was 77.8% and 66.7%, respectively. It is suggested that CEA and β-2M can monitor at least 50% of patients with colorectal cancer after recurrence and have high sensitivity to hepatic metastasis.