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给已知抗癌药物分子中引入稳定氮氧自由基,合成较母体药物高效低毒的抗癌药物已引起国内外学者的重视.我们在具有抗癌活性的鬼桕毒分子中引入稳定氮氧自由基,药理试验表明其活性保持或增加,而毒性却显著地降低.
The introduction of stable nitroxide radicals into the known anti-cancer drug molecules and the synthesis of more effective and less toxic anticancer drugs than the parent drug have attracted the attention of scholars both at home and abroad. We have introduced stable nitroxides into ghost poison molecules with anticancer activity Free radical, pharmacological tests show that its activity is maintained or increased, while the toxicity is significantly reduced.