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β-氨基酮是多种药物和天然产物分子中的关键性结构单元。通常它是由含有α-活泼氢的羰基化合物和甲醛及氨发生 Mannich 反应合成的,本文报道了一种由β-羰基醚制取β-氨基酮的新方法。我们在研究α,β-不饱和羰基化合物的反应
Beta-Aminoketones are key building blocks in many drug and natural product molecules. It is usually synthesized by a Mannich reaction between carbonyl compounds containing α-active hydrogen and formaldehyde and ammonia. A new method of preparing β-aminoketones from β-carbonyl ethers is reported here. We are studying the reaction of α, β-unsaturated carbonyl compounds