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目的观察老年癫痫患者合并使用阿司匹林(ASA)对丙戊酸钠(VPA)血药浓度的影响。方法选择门诊随访的单用VPA治疗的癫痫患者,65岁以上者为观察组,65岁以下者为对照组,测定VPA的血药浓度。对观察组,再根据有无使用ASA,比较血药浓度及肝肾功能情况。结果观察组的VPA血药浓度明显高于对照组,服用ASA与未服ASA者的血药浓度及肝肾功能无明显区别。结论老年人在临床应用VPA时,应减少剂量。老年患者使用ASA不会对VPA血药浓度产生影响。
Objective To investigate the effect of combined use of aspirin (ASA) on plasma concentration of sodium valproate (VPA) in elderly patients with epilepsy. Methods Outpatients were selected epilepsy patients treated with VPA alone, over 65 years of age as observation group, 65 years of age as a control group, determination of plasma concentration of VPA. The observation group, according to the presence or absence of ASA, compared plasma concentration and liver and kidney function. Results The plasma concentration of VPA in the observation group was significantly higher than that in the control group. There was no significant difference between the serum concentration of the VPA and the liver and kidney function in ASA and ASA groups. Conclusion In the elderly, VPA should be used to reduce the dosage. The use of ASA in elderly patients does not affect VPA plasma concentrations.