Screening and docking studies of natural phenolic inhibitors of carbonic anhydrase Ⅱ

• 出 处: 中国科学：化学英文版
• 发表日期: 2009年3期
• 关键词: carbonic anhydraseⅡ NATURAL INHIBITORS SCREENING DOCKING carbonic anhydraseⅡ na
• 基金项目: Supported by the National Natural Science Foundation of China (Grant No. 30725048),the Foundation of Chinese Academy of Sciences (West Light Program)

Carbonic anhydrase Ⅱ (CAⅡ) is an important enzyme complex with Zn2+,which is involved in many physiological and pathological processes, such as calcification, glaucoma and tumorigenicity. In order to search for novel inhibitors of CAⅡ, inhibition assay of