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1969年Piper首先报导WR-2721后,许多学者对它的抗辐射作用进行了大量研究,它不仅对骨髓型放射损伤而且对肠型放射损伤和中子损伤均有较好作用。本文在观察不同药量防护效果的同时,观察了在大剂量照射时的最低有效用药量,并以此复合应用青、链霉素,观察其防护效果。材料与方法实验动物为本院繁殖的LACA雄性小鼠,日龄70—80天,体重23—28克。照射条件 ~(60)COγ线一次全身照射,给药组为1000—3000拉德,对照组为1000—1800拉德。剂量率为71.89—64.42伦/分。用药方法 WR-2721按所需的浓度配成水溶液,照前15分钟每只小鼠腹腔注射0.2
After Piper first reported WR-2721 in 1969, many scholars have done a lot of research on its anti-radiation effects, which not only have a good effect on the bone marrow-type radiation injury but also on the intestinal-type radiation damage and neutron damage. In this paper, observed the effect of different dose of protection at the same time observed in the high dose of radiation when the minimum effective dose, and the composite application of green, streptomycin, to observe the protective effect. MATERIALS AND METHODS Experimental animals were LACA male mice, aged 70-80 days old and weighing 23-28 g. Irradiation conditions ~ (60) COγ line a whole body irradiation, the administration group was 1000-3000 rad, the control group was 1000-1800 rad. The dose rate was 71.89-64.42 lun / min. Medication method WR-2721 dubbed the required concentration of aqueous solution, according to the first 15 minutes per mouse intraperitoneal injection of 0.2