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有人提出β-肾上腺素能学说来说明支气管哮喘的发生,认为β-肾上腺素能神经系统存在着部分的或完全阻滞,支持这一假说的证据来自这样的观察即:患有支气管哮喘的病人对β-肾上腺素能阻滞剂的敏感性增强,同时还有特异的药理学、生理学以及生物化学的改变。本文研究试图使用标记DHA(双氢外搏停)结合的方法来评价哮喘病人淋巴细胞β-肾上腺素能受体,另外,也研究了氢化可的松对DHA结合的影响。资料与方法受检查的人员平均年令为32岁的10名正常人(女性7、男性3)和平均年令为39岁的11名稳定状态哮喘病人(女9、
The adversarial beta-adrenergic theory has been proposed to account for the development of bronchial asthma, suggesting partial or complete block of the beta-adrenergic nervous system and the evidence supporting this hypothesis comes from the observation that patients with bronchial asthma Sensitivity to beta-adrenergic blockers is enhanced, along with specific pharmacological, physiological, and biochemical changes. This study attempts to assess the beta-adrenergic receptors of lymphocytes in asthmatic patients using a combination of labeled DHA (dihydropyribobromide), as well as the effect of hydrocortisone on DHA binding. MATERIALS AND METHODS The average age of the inspected persons was 10 normal subjects (female 7, male 3) aged 32 and 11 stable asthma patients (female 9,