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骨康口服液是广州中医药大学附属骨伤科医院防治绝经后骨质疏松症的有效方剂，主要由淫羊藿、补骨脂、黄芪、当归、丹参等组成，具有补肾壮骨、益气健脾、活血通络之功效一为探讨其作用机理，采用放射免疫法（RIA）观察了骨康高、中、低剂量及尼尔雌醇对去势大鼠模型血清中雌二醇（E2）、降钙素（CT）和骨钙素（BGP）3种激素水平变化的影响。结果：造模前各组大鼠血清中E2、CT、BGP的含量均无显著性差异，给药3个月后骨康各剂量组大鼠3种激素水平均明显高于造模组，但均低于尼尔雌醇阳性对照组。提示骨康。服液能够通过刺激大鼠体内E2、CT、BGP的分泌而达到抑制骨吸收和促进骨形成的双重作用，此种作用虽不及尼尔雌醇强，但具有副作用小的优势。
Gukang Oral Liquid is an effective prescription for prevention and treatment of postmenopausal osteoporosis in the Orthopedics Hospital of Guangzhou University of Chinese Medicine. It is mainly composed of epimedium, psoralen, astragalus, angelica, and salvia miltiorrhiza. The efficacy of Jianpi and Huoxuetongluo was explored to investigate the mechanism of action. Radioimmunoassay (RIA) was used to observe the serum estradiol (E2) in high-, medium-, and low-dose Gukang and Nilestriol on ovariectomized rat models. ), Calcitonin (CT) and Osteocalcin (BGP) levels of three hormones. RESULTS: There was no significant difference in serum E2, CT, and BGP levels between the groups before the modeling. After 3 months of administration, the levels of the three hormones in the Gukang groups were significantly higher than those in the modeling group. Both were below the Nilestriol positive control group. Prompt bone health. The liquid can achieve the dual effects of inhibiting bone resorption and promoting bone formation by stimulating the secretion of E2, CT, and BGP in rats. Although this effect is not as strong as nilestriol, it has the advantage of small side effects.