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目的观察探讨吗替麦考酚酯治疗原发性肾病综合征(PNS)的疗效,总结其临床治疗经验和临床意义。方法选取我院2009年6月至2011年6月PNS的患者58例,按照数字表随机抽取法分成观察组与对照组,各有29例,对照组采取常规治疗+泼尼松治疗,观察组使用常规治疗+泼尼松+吗替麦考酚酯治疗,观察对比两组治疗前、治疗后2周,4周,12周,24周的24h尿蛋白定量、肌酐(Cr)、尿素氮(BUN)、甘油三酯(TG)、总胆固醇(TC)、总蛋白(TP)、血浆白蛋白(Alb)的变化。结果观察组治疗2周24h尿蛋白定量、TC水平明显下降,Alb明显上升,治疗4周TG明显降低,治疗12周开始皆基本恢复正常水平,治疗前后Cr水平无明显改变;与对照组治疗2周、4周、12周、24周的24h尿蛋白定量、肌酐Cr、BUN、TG、TC、TP、Alb比较皆有一定差异(P<0.05),具有统计学意义。结论吗替麦考酚酯治疗原发性肾病综合征(PNS)的疗效显著,明显优于常规治疗,能够明显改善临床症状,改善尿蛋白水平,安全可靠,值得临床合理推广使用。
Objective To investigate the efficacy of mycophenolate mofetil in the treatment of primary nephrotic syndrome (PNS) and to summarize its clinical experience and clinical significance. Methods Fifty-eight patients with PNS from June 2009 to June 2011 in our hospital were randomly divided into observation group and control group according to the digital table. Each group had 29 cases, while the control group received conventional therapy plus prednisone. The observation group The use of conventional treatment + prednisone + mycophenolate mofetil treatment, observe and compare 24 hours before treatment, 2 weeks after treatment, 4 weeks, 12 weeks, 24 weeks of urinary protein, creatinine (Cr), urea nitrogen BUN, triglyceride, total cholesterol, total protein and serum albumin. Results In the observation group, urinary protein excretion was quantified 24 h after treatment, TC level was significantly decreased, Alb significantly increased, TG decreased significantly after 4 weeks treatment, The urinary protein excretion, creatinine Cr, BUN, TG, TC, TP and Alb in 24 hours, 4 weeks, 12 weeks and 24 weeks were all significantly different (P <0.05), with statistical significance. Conclusion Mycophenolate mofetil treatment of primary nephrotic syndrome (PNS) was significantly better than conventional treatment, can significantly improve clinical symptoms, improve urinary protein levels, safe and reliable, it is worth promoting the clinical rational use.