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Thermo-responsive polyrotaxane (PR)-based triblock copolymers were synthesized via the atom transfer radical polymerization (ATRP) of N-isopropylacrylamide initiated with self-assemblies made from a distal 2-bromoisobutyryl end-capped Pluronic 17R4 (PPO14-PEG24-PPO14) with a varying amount of β-cyclodextrins (β-CDs) in the presence of Cu(I)Cl/PMDETA at 25 °C in aqueous solution. The molecular structure was characterized by means of H NMR, FTIR, WXRD, GPC, TGA and 1 DSC analyses. About half of β-CDs are still entrapped on the Pluronic 17R4 chain while the number of incorporated NIPAAm monomers is nearly a double feed value in the resulting copolymers. The aggregate morphologies in aqueous solution were evidenced by TEM observations. A two-step thermo-responsive transition arising from a combination of a polypseudorotaxane middle block with poly(N-isopropylacrylamide) flanking blocks was also demonstrated by turbidity measurements. Given their thermo-responsive behavior in aqueous solution, these PR-based triblock copolymers show the potential to be used as smart materials for the controlled drug delivery systems, biosensors, and the like.
Thermo-responsive polyrotaxane (PR) -based triblock copolymers were synthesized via the atom transfer radical polymerization (ATRP) of N-isopropylacrylamide initiated with self-assemblies made from a distal 2-bromoisobutyryl end-capped Pluronic 17R4 (PPO14-PEG24- PPO14) with a varying amount of β-cyclodextrins (β-CDs) in the presence of Cu (I) Cl / PMDETA at 25 ° C in aqueous solution. The molecular structure was characterized by means of H NMR, FTIR, WXRD, GPC, TGA and 1 DSC analyzes. About half of β-CDs are still entrapped on the Pluronic 17R4 chain while the number of incorporated NIPAAm monomers is nearly a double feed value in the resulting copolymers. The aggregate morphologies in aqueous solution were evidenced by TEM observations. A two-step thermo-responsive transition arising from a combination of a polypseudotoxane middle block with poly (N-isopropylacrylamide) flanking blocks was also demonstrated by turbidity measurements. Given their thermo-responsive behavior in aqueous so lution, these PR-based triblock copolymers show the potential to be used as smart materials for controlled drug delivery systems, biosensors, and the like.