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热休克蛋白HSPs 是分布于所有生物体的一类高度保守蛋白。许多环境应激包括温度改变、炎症、发热、照射、病毒感染、恶性转化、缺氧以及接触氧化剂、重金属离子、乙醇等,都能引起这种蛋白合成反应性增加。丝裂原和淋巴因子诱导的T 淋巴细胞活化也有同样作用。应激对HSPs 的诱导反应迅速且剧烈,可以认为是一种紧急应答。但HSPs 也能在低水平上持续表达,它在维持正常细胞功能上起关健性作用。HSPs 分成所谓的“小”HSPs,GroEL相关HSPs,HSP-70组,HSP-90组和HSP
Heat Shock Proteins HSPs are a highly conserved class of proteins that are found in all organisms. Many environmental stresses, including temperature changes, inflammation, fever, irradiation, viral infection, malignant transformation, hypoxia, and exposure to oxidants, heavy metal ions, ethanol and the like, all contribute to this increased protein synthesis reactivity. Mitogen and lymphokine-induced T lymphocyte activation also has the same effect. Induction of stress on HSPs quickly and intensely, can be considered an emergency response. However, HSPs are also consistently expressed at low levels and play a key role in maintaining normal cellular function. HSPs are classified into so-called “small” HSPs, GroEL-related HSPs, HSP-70 group, HSP-90 group and HSP