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应用免疫组化和免疫电镜方法研究了新疆Ｋａｐｏｓｉ肉瘤（ＫＳ）组织内ｐ５３蛋白的表达情况，结果表明１６例ＫＳ组织内均存在着ｐ５３蛋白的异常表达，而１０例皮肤纤维瘤仅有２例阳性，正常皮肤均为阴性。作者推测ｐ５３蛋白基因突变可能在ＫＳ发病机制上起一定作用
Immunohistochemistry and immunoelectron microscopy were used to study the expression of p53 protein in Xinjiang Kaposi’s sarcoma (KS). The results showed that there were abnormal expressions of p53 protein in 16 KS tissues, while 10 cases had only 2 cases of dermal fibroids. Positive, normal skin was negative. The authors speculate that p53 protein gene mutation may play a role in the pathogenesis of KS