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目的描述甲型副伤寒爆发疫情中病例的耐药特征和评估治疗效果。方法对爆发疫情中分离出的菌株进行药敏试验。计算从确诊病例治疗到体温正常所需的时间,以及通过粪检检查病例在完成治疗1周后是否继续排菌。结果所分离培养出的48株甲型副伤寒沙门菌有47株对萘啶酮酸耐药。48例确诊病例从治疗到体温恢复正常平均所需的时间为4.8d。所有确诊病人体温恢复正常1周后进行初次粪检仍有10%的病例继续排菌。消除病例带菌状态,从治疗时间算起,最长需要治疗60d。结论彻底消除甲型副伤寒带菌状况比较困难,需进一步研究更有效的治疗方案。
Objective To describe the drug resistance characteristics of cases of paratyphoid A outbreak and evaluate the therapeutic effect. Methods Susceptibility test was carried out on the strains isolated from outbreaks. Calculate the time from treatment of the diagnosed case to normal body temperature, and whether excretion of bacteria continues after one week of treatment is checked by fecal examination. Results Forty-eight isolates of 48 strains of Salmonella paratyphi A were resistant to nalidixic acid. The time required for 48 normalized cases to return from treatment to body temperature was 4.8 days. All diagnosed patients returned to normal temperature after 1 week for the first time stool still 10% of the cases continue row bacteria. Elimination of cases carrying status, counting from the treatment time, the longest need for treatment 60d. Conclusion It is difficult to completely eliminate the pathogen of Paratyphoid A, and further research on more effective treatment is needed.